Some experts have reported that administering vitamin D to these people helps ease these symptoms., People who have the muscle disease amyotrophic lateral sclerosis (ALS) are also at higher risk for muscle pain while taking statins., Millions of Americans take statins because they effectively target all aspects of one's lipid profile by lowering low-density lipoprotein (LDL) cholesterol and triglycerides while raising high-density lipoprotein (HDL) cholesterol. If detected, statins will be stopped right away. © 2005-2020 Healthline Media a Red Ventures Company. The relationship of vitamin D deficiency to statin myopathy. Some people are more likely to develop side effects from statins, including muscle pain. 2016;67(20):2395-2410. doi:10.1016/j.jacc.2016.02.071, Ward NC, Watts GF, Eckel RH. Like so many of the comments, the doctors just blew it off saying it wasn't the statin. They also reduce the chance of stroke and heart attack.. Thank you, {{}}, for signing up. While there are several theories as to why statins may cause muscle pain, none have been confirmed. 2018;7(19):e009835. J Am Heart Assoc. Tongue-tie surgery is a small procedure that can help some babies with breastfeeding. J Clin Lipidol 2014; 8:S58. With less energy, your muscle cells may not be able to work properly. N Engl J Med. Rhabdomyolysis, or the breakdown of muscle tissue, is a rare side effect of statins that can also cause muscle pain. MedlinePlus. The severity of these side effects can range from mildly irritating to almost unbearable. Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common, Effects of statins on skeletal muscle: a perspective for physical therapists, Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trials, Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management, Statin therapy, myopathy and exercise–a case report, An assessment by the statin muscle safety task force: 2014 update, The relationship of vitamin D deficiency to statin myopathy, Amyotrophic lateral sclerosis associated with statin use: A disproportionality analysis of the FDA's adverse event reporting system, National trends in statin use and expenditures in the U.S. adult population From 2002 to 2013: Insights from the Medical Expenditure Panel Survey, Have certain conditions like hypothyroidism, Consume large amounts of grapefruit or cranberry juice. Certain factors may increase this risk. The following are the three most common forms of statin-related muscle pain: 1. Looking to start a diet to better manage your cholesterol? The time to find out if Medicare covers ambulance service is before you need one. Research has shown that the gene atrogin-1 may be the source of muscle pain in those taking statins. Sometimes this pain can be a sign of damage, which can be severe. You should know upfront that not everyone who takes a statin will have muscle pain, and muscle pain from statins might show up differently for different people. Research has suggested that taking CoQ10 supplements might lower your chances of experiencing statin-related myopathy, but available data is still not sufficient enough to back this up. Yasmine S. Ali, MD, MSCI, is a board-certified preventive cardiologist and lipidologist. If you have any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately. J Am Coll Cardiol. Lipids Health Dis. In very rare cases, statins may cause liver problems or a potentially life-threatening breakdown in muscle cells. The risk appears to be significantly lower with Lescol (fluvastatin), Pravachol (pravastatin) and Crestor (rosuvastatin). Initial blood tests should include However, the most common side effect is muscle pain and cramping. Another theory is that statins can potentially interfere with the production of CoQ10, a coenzyme in the muscles. CoQ10 assists the muscles in using the energy they need to function properly. Statins do cause muscle pain in some people, though an exact reason isn’t clear. In this condition, you may experience soreness, weakness, and tiredness in muscles. Finally a new Dr said I was allergic to all statin pills and prescribed an injection w/Repatha every two weeks and it worked. 2011;215(1):23-9. doi:10.1016/j.atherosclerosis.2010.11.039, Golomb BA, Verden A, Messner AK, Koslik HJ, Hoffman KB. They may suggest stopping treatment only briefly until the problem resolves, or not at all. Rhabdomyolysis. Providence Medicare Advantage: A Guide to Your 2021 Plan Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, What to Do If Your Baby Shows Signs of Pink Eye, What to Know If You’re Told Your Baby Needs Tongue-Tie Surgery. 2019;124(2):328-350. doi:10.1161/CIRCRESAHA.118.312782, Stroes E, Thompson P, Corsini A et al. Research has also shown that people taking Mevacor (lovastatin) have higher levels of atrogin-1 than those not taking the drug. Changing lifelong eating habits can be scary at first, but our guide will make it easier. The following are the three most common forms of statin-related muscle pain: Muscle problems related to statin therapy usually begin within a few weeks to a few months after beginning treatment. Most often when statins are responsible for the muscle pain, one of three things happen. Although your muscle pain could be caused by the drug, it might be caused by something else. Statin therapy, myopathy and exercise–a case report. Together, you and your doctor can find a medication that helps you control your cholesterol level while properly balancing effectiveness and side effects. Statin toxicity. As such, it's recommended that the dosage of simvastatin be limited to 40 milligrams (mg) per day, which can reduce the risk of muscle problems. Our website services, content, and products are for informational purposes only. These plans provide the same coverage as…. Eur Heart J. Additionally, a 2016 study showed statin-associated autoimmune myopathies are also a side effect of statins. In those serious cases, treatment is needed to help clear up the infection. Sometimes switching to a different type of statin can resolve muscle-related pain and side effects, so your doctor may recommend this if you're in search of relief. Statins are a group of cholesterol-lowering medications. Here's what you need to know. This gene turns on at the beginning stages of the breakdown of muscle, which is associated with illnesses such as cancer, sepsis, and AIDS. (When the atrogin-1 gene is not active, muscle wasting does not occur.). When a patient taking statins reports muscle pain or weakness, a detailed history should be taken to assess predisposition to myopathy, and a physical examina-tion should be done to exclude other common conditions (box 2). Atorvastatin (the generic name) and Lipitor prescription side effects are common to people taking these statins for their cholestoral lowering benefits. Effects of statins on skeletal muscle: a perspective for physical therapists. Additionally, scientists may be able to manipulate this gene, or others involved, to prevent muscle damage caused by statins. High-dose simvastatin (brand name Zocor) appears to present a higher risk for muscle pain than other statin drugs. 2011;109(2):123-6. doi:10.1161/CIRCRESAHA.111.248872, Di stasi SL, Macleod TD, Winters JD, Binder-macleod SA. Managing statin muscle pain. In rare cases, the impact of these drugs on the muscles can be serious. PCSK9 Inhibitors for Cholesterol—Are They Really Miracle Drugs? Statins are a common group of drugs prescribed by doctors to treat high cholesterol. Read our, Medically reviewed by Jeffrey S. Lander, MD, Medically reviewed by Yasmine S. Ali, MD, MSCI, Medically reviewed by Richard N. Fogoros, MD, Side Effects of Statin Drugs That Can Affect Your Muscles, Side Effects of Statin Drugs for Cholesterol, How Zocor (Simvastatin) Works to Lower Your Cholesterol. 2016;374(7):664-9. doi:10.1056/NEJMra1515161, An Overview of Muscle Pain in Statin Users, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. If you have muscle weakness with or without pain, you need to contact your doctor now. This is important because too much cholesterol in your bloodstream increases your risk of heart attack and stroke. doi:10.1161/JAHA.118.009835, Thompson PD, Panza G, Zaleski A, Taylor B. Statin-associated side effects. What Is Delayed Onset Muscle Soreness (DOMS) and What Can You Do About It? Besides muscle pain, these can include liver damage, digestive problems, increased blood sugar, memory loss and confusion.. Lee D, Goldberg A. Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common. When the drug is removed from the cells, it does not appear to cause muscle damage. In the future, this may allow your healthcare professional to identify if you are at risk for statin-related muscle pain. Statin use has also been associated with difficulties with memory and reasoning, although there is no clear evidence that the drugs were responsible. Pink eye in babies is common but can sometimes be more serious. Medicines that dull pain are analgesics. Myositis: Myositis, a type of myopathy, causes muscle pain and inflammation, as well as an elevation in CK (a muscle enzyme) levels in the blood. According to the FDA, the following statins contain specific warnings on the package inserts about muscle pain and rhabdomyolysis: Rhabdomyolysis sounds scary, but the average statin user does not have to worry about developing this disorder. 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